Niclosamide Bolus 1250 mg
Ka ārai te Niclosamide Bolus i te phosphorylation i roto i te mitochondria o ngā cestodes. I roto i te vitro me te in vivo, ka mate ngā wāhanga scolex me te proximal ina pā ki te rongoā. Ka taea te keri i te scolex kua wetekina i roto i te whekau; nō reira, kāore pea e taea te tautuhi i te scolex i roto i te paru. He taenicidal te mahi a te Niclosamide Bolus, ā, kāore i te whakakore i ngā wāhanga anake engari i te scolex anō hoki.
Ko te mahi a te Niclosamide Bolus ki ngā noke te āhua nei nā te aukati i te mitochondrial oxidative phosphorylation; ka pāngia hoki te hanga ATP anaerobic.
Ko te mahi cestocidal a te Niclosamide Bolus nā te aukati i te mimiti o te hukahuka e te kutukutu rīpene, me te wetewete i te hononga o te tukanga phosphorylation oxidative i roto i te mitochondria o ngā cestode. Ko te waikawa lactic kua kohia mai i te aukati i te huringa Krebs ka patu i ngā kutukutu.
Ngā tohu
E tohuhia ana te Niclosamide Bolus mō te whakaekenga kutukutu rīpene o ngā Kararehe, ngā Manu, ngā Kurī me ngā Ngeru, tae atu ki te paramphistomiasis pakari (Amphistomiasis) o ngā Kau, ngā Hipi me ngā Koati.
Ngā kutukutu rīpene
Kau, Hipi, Koati me te Tia: Moniezia Species Thysanosoma (Nuku Rīpene Āwhata)
Ngā kurī: Dipylidium Caninum, Taenia Pisiformis T. hydatigena and T. taeniaeformis.
Ngā hōihoNgā mate urutā anoplocephalid
ManuRaillietina rāua ko Davainea
Āmisitomiasis: (Ngā Paraphistomes Kore-Pakeke)
I roto i ngā kau me ngā hipi, he tino noa ngā piro rumen (momo Paramphistomum). Ahakoa he iti noa te pānga o ngā piro pakeke e piri ana ki te pakitara rumen, ko ngā mea kāore i te pakeke he tino mate kino ka puta he kino nui, ka mate hoki i a rātou e heke ana i roto i te pakitara duodenal.
Me whakapae kei te mate amphistomiasis ngā kararehe e whakaatu ana i ngā tohu o te kore kai nui, te nui o te inu wai, me te mate korere haunga wai, ā, me rongoā tonu ki te Niclosamide Bolus hei ārai i te mate me te ngaronga o te whakaputanga, nā te mea he tino kaha tonu te Niclosamide Bolus ki ngā piroriki kāore anō kia pakari.
Te hanganga
Kei roto i ia polus kāore i pania:
Niklosamide IP 1.0 karamu
Te whakahaere me te horopeta
Niclosamide Bolus i roto i te whāngai, i te mea pērā rānei.
Mō ngā kutukutu rīpene
Kau, Hipi me Hōiho: 1 karamu te nui mō te taumaha tinana 20 kg
Ngā Kurī me ngā Ngeru1 karamu horopeta mō te taumaha tinana 10 kg
Manu1 karamu te nui o te horopeta mō ngā manu pakeke e 5
(Tata ki te 175 mg ia kg te taumaha tinana)
Ki ngā Amphistomes
Kau me Hipi:Te horopeta teitei ake i te tere o te 1.0 karamu horopeta / 10 kg te taumaha tinana.
Haumaru:He whānui te haumaru o te Niclosamide bolus. Kua kitea he kore paitini te nui rawa o te Niclosamide tae atu ki te 40 ngā wā i roto i ngā hipi me ngā kau. Mō ngā Kurī me ngā ngeru, kāore he pānga kino e puta mai i te rua o te horopeta kua tūtohutia engari ko te ngawari o te paru. Ka taea te whakamahi haumaru i te Niclosamide bolus i ngā wāhanga katoa o te hapūtanga me ngā tāngata ngoikore me te kore he pānga kino.
